Autophagy protects against genome instability and prevents necrosis, giving it a key role in preventing diseases such as cancer, neuro-degenerative diseases, cardio-vascular diseases, diabetes, liver disease, autoimmune diseases and infections. Taking steps to make sure autophagy is activated means increasing the odds of living a longer, healthier life.
In addition to the boosting autophagy, numerous studies have shown that the ingredients included in this formulation have potent anti-inflammatory and anti-oxidant properties, as measured by C-Reactive Protein (or CRP) and Total Antioxidant Status (or TAS).
- A member of the vitamin B family, it is a SIRT1 activator that induces autophagy by stimulation of deacetylases. Also known to improve the HDL/LDL profile when taken at pharmacological levels.
- Anti-oxidant, anti-artherogenic, and anti-carcinogenic properties. It is also known to improve the bio-availability the other active ingredients in this supplement, thereby making the whole greater than the sum of its parts. See here and here.
- This compound has been well-known for a while now. It induces autophagy through the mTOR-ULK1 pathway. Reduces inflammation, induces cancer cell death and protects against oxidative damage.
- A close “cousin” of resveratrol, the only difference being two methoxy groups on the pterostilbene molecule that replace hydroxy groups on the resveratrol molecule. It appears to be much more well-absorbed following oral ingestion and may be a more potent anti-oxidant and anti-cancer molecule, while not being as effective as an anti-inflammatory agent. Studies have shown it to have decreased cholesterol and blood glucose, and improved insulin sensitivity.
- Short for epigallocatechin-3-gallate, it also inhibits a range of acetyltransferases. The main active ingredient in green tea. It is also widely believed to be cardio-protective, neuro-protective, anti-obesity, anti-carcinogenic, anti-diabetic, anti-artherogenic, liver-protective and beneficial for blood vessel health.
Included in the Autophagy Stack in its capacity as an acetyltransferase inhibitor, it exhibits many of the same anti-inflammatory properties as other polyphenols.
How To Tell It Works
At this point, you are probably thinking to yourself “all of this science sounds terrific, but how do we know that Autophagy Stack is working?” Unfortunately, there is no diagnostic test that will tell you your level autophagy. However there is a study that may shed some light on this issue. The study tested the effects of a very similar mix of ingredients – it had resveratrol, pterostilbene, quercetin and niacinamide in common – called NS-5. The result? Decreased nitric oxide and C-reactive protein (the most commonly used inflammation marker), and increased total anti-oxidant status.
In addition, the study divided the subjects into 2 groups, one with normal cholesterol levels, and another with elevated cholesterol. In the group with elevated cholesterol, NS-5 lowered triglycerides, total cholesterol and LDL-cholesterol, whereas the healthy group was unaffected. The study even showed mild improvements in blood pressure!
While directly measuring autophagy isn’t possible yet, blood panels are a very good indicator that caloric restriction mimetics have many beneficial properties. Inflammation seems like an especially good proxy for autophagy, which makes sense, since poorly functioning autophagy means the cells aren’t getting rid of the junk, which would cause inflammation.
Certificate Of Analysis
You can view the certificate here to ascertain the purity of our ingredients, and to verify that it rates well below the guidelines for bacterial and heavy metal contaminants.
2 capsules a day in a fasted state, as soon as you wake up. Then allow for at least 3 to 4 hours before consuming anything with calories (N.B.: some people believe that anything besides water may interfere with the fasted state and autophagy. We do not have a strong view on this matter). This should be no problem if you are already practicing intermittent fasting. Consuming it right before bed if you have eaten an early dinner should also be very effective. Combining the two – right before bed and right after waking up – will likely give you the best results.