Autophagy could be one of the most important bodily processes we know of. Autophagy and finding a potent autophagy supplement are some of the hottest topics in the health and fitness world. There are thousands of new scientific studies coming out every single year on what autophagy is, when autophagy occurs, how to initiate autophagy, and why it’s so good for you.

But there’s a big problem with it.

If you don’t know, autophagy is the body’s recycling program.

When autophagy starts inside each of your cells, it lets you recycle broken or old parts into new sources of energy or raw materials.

So far, science has shown that when autophagy does occur, it is incredibly healthy. It delays aging, protects your body from cardiovascular and neurodegenerative diseases, fights diabetes, and can also prevent infections.

But there’s a big problem with autophagy: it is very hard to induce.

Perhaps the most effective way to initiate autophagy is through fasting and nutrient restriction. When our cells are deprived of nutrients, they begin autophagy to break down old and damaged parts for energy.

This is one reason why intermittent fasting and autophagy go hand in hand. Intermittent fasting allows practitioners to initiate autophagy daily and reap the benefits on a regular basis.

But if you don’t want to fast for 12 to 16 hours every single day, there could be a way to speed up the process with an autophagy supplement.

Meet the World’s First Autophagy Supplement

The Autophagy Stackautophagy supplement is the world’s very first autophagy supplement that mimics how you initiate autophagy at the molecular, physiological level.

Not only could the Autophagy Stack allow you to shorten the fasting window, but it also delivers a powerful blend of anti-inflammatory and antioxidant ingredients.

How the Autophagy Stack Works

We mentioned above that one way to start autophagy is to fast for 12 to 16 hours to sufficiently deplete the nutrients in your cells.

Specifically, the lack of cellular nutrients causes the depletion of something called intra-cellular acetyl coenzyme A (AcCoA) and the deacetylation of cellular proteins.

However, these effects can most likely be replicated with an autophagy supplement using:

  • AcCoA depleting agents – These agents decrease intracellular levels of AcCoA by stopping its production.
  • Acetyltransferase inhibitors – These molecules inhibit the enzymes that transfer acetyl groups from AcCoA to other molecules. These enzymes are called acetyltransferases.
  • Deacetylase activators – These activators increase production of deacetylases, which facilitate the removal of acetyl groups from leucine residues.

Together, these three effects begin autophagy by mimicking what happens at the cellular level when you fast.

What’s Inside the Autophagy Stack

The Autophagy Stack uses a combination of 6 different clinically tested ingredients. Each one of these ingredients (except for quercetin, which is a proven and natural absorption enhancer) performs one of the three functions mentioned above and mimics how you start autophagy.


Niacinamide is a well-known B vitamin. It is included in the Autophagy Stack because niacinamide activates a cellular protein called SIRT1, which induces autophagy by stimulation of deacetylases. As an added bonus, niacinamide also improves your HDL/LDL profile.


Quercetin improves the bioavailability of the other active ingredients in the Autophagy Stack, thereby making the whole greater than the sum of its parts. But it also has antioxidant, anti-atherogenic, and anti-carcinogenic properties and is a perfect addition to this autophagy supplement.


Curcumin is a polyphenol found in turmeric. Humanity has prized curcumin for thousands of years as an antioxidant, anti-aging, and anti-inflammatory ingredient. We include curcumin in the Autophagy Stack for its capacity as an acetyltransferase inhibitor.


You may remember Resveratrol from a few years ago when it was found in abundance in red wine. Resveratrol induces autophagy through the mTOR-ULK1 pathway and reduces inflammation, causes cancer cells to die and is another powerful antioxidant.


Pterostilbene is a close “cousin” of Resveratrol. The only difference between them is two methoxy groups on the pterostilbene molecule that replace hydroxy groups on the resveratrol molecule. Pterostilbene might have an advantage over Resveratrol in that it looks to be better-absorbed through oral ingestion. Some studies have shown that it might be a more potent antioxidant and anti-cancer molecule. However, it may not be as effective an anti-inflammatory agent. Another benefit of Pterostilbene is that it decreases cholesterol and blood glucose and improves insulin sensitivity.


EGCG stands for epigallocatechin-3-gallate. This is another inhibitor of a range of acetyltransferases. EGCG is the main active ingredient in black and green teas. EGCG protects your heart, brain, and provides anti-obesity, anti-cancer, anti-diabetic, and anti-atherogenic properties, as well as promoting liver and blood vessel health.

How to Get the Autophagy Stack

The Autophagy Stack is made by New York-based Accord Nutrition. We are a team of health, fitness, longevity, and technology enthusiasts. Our mission is to help as many people as possible extend their healthspan through new health breakthroughs. Autophagy is a very promising physiological mechanism that we believe could help people do exactly that and we are so proud to tell you more about our autophagy supplement.

Click here to learn more about the Autophagy Stack.

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